In this article, you will find the information about the scientific basis of HGH work: HGH structure, functions, effects on the body, and how you can benefit from it.
Human growth hormone (HGH) is a 191-amino acid, the hormone which is secreted by the anterior pituitary. Growth hormone is involved in many body processes during the whole life. It promotes the growth of bones, regeneration of skin, muscle growth and loss of fat. Also, HGH participates in the nutrient metabolism of proteins, fats, and carbohydrates.
Recombinant human growth hormone (rHGH) is a synthetic type of this hormone. Synthesized in 1985, rHGH is produced by the bacterium E.coli, which is genetically changed.
Human growth hormone that circulates in the body has more than 100 forms of different weight and quality. 22-kDa isoform constitutes 20% of all HGH.
The molecule of HGH has the peptide structure and consists of 20 types of amino acids.
Growth hormone is controlled by two processes, synthesis and secretion, which don’t coincide. HGH synthesis in the pituitary is a permanent process which continues the whole day on the same level when its secretion has the pulsatile nature. Secretion of growth hormone is regulated by 2 hormones, somatoliberin and somatostatin, which have opposite natures. The first one deliberates HGH, while the second hormone blocks the deliberation. During the day, their balance changes, and GH is secreted into the bloodstream.
Both somatostatin and somatoliberin are secreted by the hypothalamus and bound to receptors of somatotropic cells in the pituitary, thus regulating HGH secretion.
Growth hormone influences the body both by itself only and through so-called somatomedins – A, B, C.
IGF-1 has significant anabolic effects. Most of the HGH effects, including the muscle growth, fat burning, healing of injuries, muscle cell division, are performed by the IGF-1.
It is produced mostly by the liver, and, in low amounts, by muscle, bone, and skin tissue. Then IGF-1 circulates to tissues and enhances their growth.
IGF-2 (insulin-like growth factor) is responsible for child growth before birth. IGF-2 divides body cells, including muscle and bone cells. Researchers have discovered , that IGF-2 local injections stimulate bone development.
Vitronectin – its functions haven’t been fully discovered yet, but the research shows that vitronectin is likely to have some anabolic functions.
Also, GH influences body on its own, by increasing metabolic velocity (REE) by 20%, which is useful for fat loss .
GH secrets in a pulsating way as every 3-5 hours its level increases from 1 up to 5-10 ng/ml. The highest peak is observed in first hours of the night when 70 % of the GH daily amount is secreted.
HGH level decreases with age. The process of HGH diminishing runs since birth and continues until death. The most dramatic decrease is observed when a person reaches 30. In this age, many people begin to experience symptoms of GH deficiency. The pituitary of a teenager secrets 2 mg (about 6 IU) of HGH each day, this level decreases to 0,75 mg (2 iu) at 20, and to 0,2 mg at the early forties.
The number of daily secretions decreases as well – from 8 to 4 with age. The decrease of HGH is connected with changes in appearance, such as the loss of muscle mass, fat gaining, or occurring of wrinkles.
As the highest peak of GH is observed during the first hour of sleep, you need to sleep well
There are many studies about exercises and GH secretion. Kraemer and Godfrey [7,10] have conducted several experiments to explore growth hormone response on different heavy-resistance exercise protocols. The factors they examine include the exercises heaviness, number of exercises and sets, duration of each set, rest time between sets.
Based on these experiments, we can outline training principles for GH secretion:
The experiment by W.M. Hunter  has proved that aerobic exercises can greatly increase HGH secretion up to 40- 100 ng/ml (look at the pic), which is higher than the average daytime level by 8-20 times! It is caused by the high level of fat acids observed during the aerobic workout, which sends a signal to the pituitary to secrete growth hormone for utilization of the fatty acids.
Methods to induce growth hormone secretion include:
HGH patches don’t have a clear mechanism of action. They seem to be a kind of scam.
Although synthetic growth hormone was created to treat children who suffer from GH deficiency, now the main scope of HGH usage is health: anti-aging therapy and sport.
After HGH had been discovered, it rapidly became popular in bodybuilding due to its strong anabolic effects, such s muscle gain, muscle cells division, fat burning. Growth hormone is a philosopher’s stone for bodybuilding because it builds muscles and burns fat at the same time.
For bodybuilding purposes, HGH should be used at least for 2-3 months to witness a significant change in the body composition. The optimal dosage ranges depending on the purpose, weight and athletic experience, between 4 and 20 ius. 4-8 ius dosage provides significant fat burning effect, but the optimal dosage for muscle gains starts from 10 IUs daily.
HGH half-life period is 4-6 hours, and thus daily dosage needs to be divided into 3 injections with equal pauses. The optimal administration is an injection in the morning and the next one 6 hours later.
2) Derek Le Roith, Carolyn Bondy, Shoshana Yakar – The Somatomedin Hypothesis: 2001
3) D M Shinar, N Endo, D Halperin – Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone
4) R R Davies D G Johnston – Growth hormone releasing factors
4) Helen Robso n, Thomas Siebler, Stephen M Shalet – Interactions between GH, IGF-I, Glucocorticoids, and Thyroid Hormones during Skeletal Growth
5) Christian Jux, Kathrin Leiber, Ulrike Hügel – Dexamethasone Impairs Growth Hormone (GH)-Stimulated Growth by Suppression of Local Insulin-Like Growth Factor (IGF)-I Production and Expression of GH- and IGF-I-Receptor in Cultured Rat Chondrocytes
6) Len Kravitz, Ph.D. and Lance Dalleck, Ph.D. – Lactate Theshold Training
7) William J. Kraemer, Keijo Häkkinen, Robert U. Newton – Effects of heavy-resistance training on hormonal response patterns in younger vs. older men
8) Craig BW1, Brown R, Everhart J. – Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects.
9) Hunter W. M. Fonseka C. C. and; Passmore R – the role of growth hormone in the mobilization of fuel for muscular exercise
10) William J. Kraemer and Nicholas A. Ratamess – Hormonal Responses and Adaptations to Resistance Exercise and Training
Yes, HGH is safe, if you don’t have problems with health and if your dosage is low (less than 10-15 IU). First of all, HGH is not a toxic substance; it is simply a 191-amino acid chain, the peptide hormone which is secreted by the pituitary.
Despite its name, growth hormone, HGH responsible for many processes in the human body, not only for the linear growth of bones. High level of growth hormone helps improve your posture and form body composition with strong muscles and low amount of fat. HGH also helps the immune system to keep working well and the cartilage to stay healthy.
So, as you can see, HGH is safe for your body in normal amounts, but it can be dangerous if it is exogenous. Let’s talk about HGH risks and how to avoid them.
The excessive use of HGH can lead to the following Side Effects:
Growth hormone can be used for several purposes, such as to lose fat, gain muscles, become younger, or grow taller.
HGH is used for bodybuilding much more often than for anti-aging purpose or any other one, so you should know all HGH side effects and ways to avoid them. You can read the article about this.
Briefly, if you are a healthy young man, you can use HGH at a dosage of 4-10 IU. If you want to increase this dosage, you need to add exogenous insulin to help your pancreas. You can add insulin at lower dosages too if you want to make your cycle more efficient.
Cycle duration. Safe HGH cycle duration is 3 months, it is due to the probability of side effects s. 3 months at 4-8 IU is enough to gain 10-15 lbs of muscles and lose the same amount of fat, and thus greatly improve your physique.
Ronald Klatz, an expert in HGH for anti-aging argues that an optimal dosage for anti-aging is 1-3 IU/ day for 6 months. Then it requires the same rest period. For 6 month of use, the appearance changes greatly as the skin becomes elastic, wrinkles disappear, nails and hair improve as well. A person looks 10 years younger.
The myth that growth hormone affects libido is connected with another myth that HGH is a steroid. I have prepared an article about HGH and steroids in this regard. They are completely different in the structure, origin, and functions.
Growth hormone doesn’t suppress your own testosterone, so it is completely safe for libido.
HGH isn’t connected with testosterone, so it can’t induce hair loss. Conversely, HGH improves the state of hair because it accelerates the synthesis of collagen.
You can take growth hormone if you don’t have the following problems:
In this article, you will find theoretical and practical information about HGH influence on weight loss, its mechanism, principles, and practical ways to use HGH for losing weight. Besides, you will learn what diet to keep and how to combine growth hormone with fat burners.
HGH is highly popular among both professional sportsmen and amateurs. Several facts can explain this phenomenon:
HGH fat loss effects are performed due to the following properties:
Yes, it can, because your organism uses your fat as energy. Even more, growth hormone helps you gain muscles and burn fat simultaneously, thus increasing lean muscle mass.
Before starting to take HGH, evaluate the amount of body fat and decide what result do you expect.
If your body fat is 15% and you want to reduce the amount to 7-9%, you need a long cycle with a relatively low dosage of the hormone. The amount of extra fat is big, so the organism needs time to burn it, and you can’t shorten this period. Your cycle – 4-5 IU for 3-4 months.
If your body fat is already low (8-10 %) and you need to become deeply ripped, you need a higher dosage (6-10 IU) to induce the fat burning process. Your diet should be stricter. HGH will carry out two functions: preventing muscle loss and accelerating fat burning.
The most popular protocols are ED (every day) and EOD (every other day). Both work well for muscle gain, but only every-day pattern is beneficial for weight loss.
The main reason is that growth hormone influences fat by itself without the help of IGF-1. HGH level after injection is still high only for 4-5 hours instead of 10-20 hours of IGF. It means that you need to inject HGH every day or, even better, twice a day to achieve the effect of fat loss.
The first injection should be taken immediately after you wake up, before first meal. During this period, the level of sugar in the blood is low, and HGH retrieves fats more efficiently.
The second injection is better to take 6-8 hours later or before going to bed.
The diet is similar to a simple diet for cutting. First of all, leave off fast carbohydrates and animal fats. Then, gradually decrease the amount of carbs you consume and slightly increase the portion of proteins. Because growth hormone is a strong anti-catabolic substance, you can use strict diet and not be afraid to lose muscle mass. Eat every 2-3 hours.
How to train on growth hormone?
The best training program on HGH is voluminous training with a big number of sets and short breaks between them. It is not relevant for natural cutting because of catabolism, but when you take HGH for weight loss, the hormone prevents your muscles from catabolism, so you can train with lighter weights to get higher volume.
To get the result, it is extremely important to perform aerobic exercises. The best time to do that is morning fasting after you have injected HGH. The level of FFA rises in 30 minutes after the injection, and fatty acids become very easy to oxidize. A run for an hour will be very useful for your cutting.
Cardio can be frequent, 5 and more times a week.
Although l-carnitine is considered a very mild fat burner, it is highly efficient while you are using growth hormone. To understand this, let’s examine how carnitine works. The main function carnitine has the transportation of fatty acids to mitochondria, where they oxidize and converse to ATP. So, HGH and carnitine work in conjunction as HGH retrieves fatty acids and carnitine transports them. You can use this combination both for cutting to enhance HGH fat loss process and for bulking to stay leaner.
ECA (ephedrine + caffeine + aspirin)
This stack is a powerful fat burner and perhaps the best idea to accelerate your cutting. The most popular ratio is 25 mg of Ephedrine + 250 mg of caffeine + 250 mg of aspirin. These compounds give nice synergic effect. Eph induces the release of noradrenalin, which influences alpha receptors in fat cells, thus promoting lipolysis. Caffeine enhances noradrenaline, and aspirin inhibits prostaglandin (the hormone that can block noradrenaline)
ECA and HGH can complement each other and thus help achieve a better effect.
Clenbuterol works like ECA, but it stimulates beta receptors instead of alpha receptors. Clenbuterol is less effective than ECA, but it is legal in most countries. Also, you can use ECA and clenbuterol in rotation.
Another effect of Clen is the anti-catabolic one.
Consider these factors:
Protocol for one month of cutting
Week 1-2: HGH (4-6 IUs) with ECA (2 times a day) and L-carnitine (1,5 – 2 g).
Week 3-4: HGH (4-6 IUs) with Clenbuterol (40-120 mg a day; the dosage rises during the usage) and L-carnitine (1,5 – 2 g).
Then you can repeat this protocol once more. Rotation of Clen and ECA allows receptors to “clean” and become sensitive again. Growth hormone efficacy only decreases if you take it for a very long period (half a year) or if HGH is of low purity, with a high percent of bacterial residue.
You can read our article about HGH brands, where you will find comprehensive information about the growth hormone market.
In short, to choose HGH brand, you need to take into account its quality and price. Today, Chinese officially manufactured HGH, which includes Jintropin, Ansomone, and Hygetropin, has the best cost-to-quality ratio.
You can find them in this online shop for best prices.
Shipping – 7-10 days, EMS, 30 dollars.
Free shipping on orders of 300 IU or more.
If you have any questions, feel free to send us an e-mail.
1) Kim KR1, Nam SY, Song YD – Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults.
2) Hong Wang, Robert H. Eckel – Lipoprotein lipase: from gene to obesity
3) Paul G. Shekelle – Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic Performance
From this article, you will learn theoretical and practical information about HGH and steroids. You will find out whether HGH is a steroid, what to choose: HGH or steroids, to improve the physique and how you can combine them for bodybuilding purposes.
Also, see our HGH for sale offers
No, HGH and steroids have entirely different chemical structures, so the word combination “HGH steroids” is incorrect. Steroids are variations of testosterone, synthetically produced to be used for trauma treatment or sports purposes. Steroids possess a cycloalkane structure.
Human growth hormone is a hormone, polypeptide chain of 191 amino acids connected with peptide chains. HGH is secreted by the pituitary gland, while testosterone is produced by the testicles.
Despite differences in the structure, both steroids and HGH are defined as strong anabolic substances, which can be combined because they influence different receptors. You will learn below how to do it specifically.
Growth hormone functions is promoting of muscle growth and burning of fat.
HGH performs fat burning directly. Growth hormone takes fats out of their storage into the bloodstream. Then, they are transported to mitochondria, oxidized and converted to ATP (universal energy). It means that HGH makes fats an energy source, instead of carbohydrates. As a result, you lose your fat when you take HGH. Fat loss is especially visible in the belly area, where fat is easier to retrieve.
Muscle growth activity of HGH is performed by IGF-1 (insulin-like growth factor 1). IGF is produced when HGH interacts with receptors in the liver, being converted into IGF. Then, IGF circulates to muscle cells, binds to IGF receptors, thus accelerating protein synthesis.
These two effects are simultaneous as you lose fat and gain muscles at the same time.
Mechanism of steroids is different from the HGH one. After they get to the blood, steroids spread through the body and react with skeletal muscle tissue, skin, fat, bones, and parts of the brain, significantly changing their state.
Anabolic steroids can easily go through the muscle cell membrane, which consists of fats and binds to androgen receptors inside the cells. Different steroids have different ability of binding to receptors, which is measured by the anabolic index. For example, testosterone index is 1; trenbolone has 5. It means that tren can stabilize the receptor five times more efficiently.
To decide what to choose, HGH or steroids, you need to know what result do you expect to get.
Growth hormone is useful to gain lean muscle mass simultaneously with losing fat. Growth hormone won’t give you dramatic gains; however, the mass you’ve gained will remain after the cycle. Steroids fit better to obtain huge muscle mass rapidly, for two months.
However, you don’t need to choose between HGH and steroids. You can combine them to get advantages of both drugs.
Combination is a good idea for the following reasons:
This option is the easiest one. You can use long esters, such as cypionate, enanthate or Sustanon.
The dosage depends on your experience. The optimal proportion is 1/100.
For example, 5 IU of HGH/day + 500 mg of test-C
Divide your daily dosage of HGH into two injections. Inject the first after you wake up and the second 6-8 hours after it or before retiring to bed.
Combination options can be divided into two parts: for bulking and for cutting. In the first case, HGH will give you the ability to gain lean muscle mass, while in the second it will accelerate fat loss.
Bulking cycle may include strong substances, such as Testosterone, Deca, Dbol, or Trenbolone.
Test E (500 mg) + Deca (500 mg) + Dbol (30 mg) + HGH (5-7 IUs).
A cutting cycle includes steroids that burn fat: Winstrol, Anavar, Trenbolone. You also need to increase the dosage of HGH if your cycle is short and you want to burn fat efficiently.
Winstrol/Anavar – 50 mg/day + Trenbolon E (200-300 mg/week) + 10-15 IUs of HGH.
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